Noninvasive Assessment of Advanced Fibrosis Based on Hepatic Volume in Patients with Nonalcoholic Fatty Liver Disease.
- Author:
Tatsuya HAYASHI
1
;
Satoshi SAITOH
;
Kei FUKUZAWA
;
Yoshinori TSUJI
;
Junji TAKAHASHI
;
Yusuke KAWAMURA
;
Norio AKUTA
;
Masahiro KOBAYASHI
;
Kenji IKEDA
;
Takeshi FUJII
;
Tosiaki MIYATI
;
Hiromitsu KUMADA
Author Information
- Publication Type:Original Article
- Keywords: Liver cirrhosis; Fibrosis; Gadoxetate disodium; Magnetic resonance imaging; Non-alcoholic fatty liver disease
- MeSH: Body Mass Index; Fibrosis*; Humans; Liver Cirrhosis; Magnetic Resonance Imaging; Methods; Non-alcoholic Fatty Liver Disease*; Retrospective Studies; ROC Curve
- From:Gut and Liver 2017;11(5):674-683
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Noninvasive liver fibrosis evaluation was performed in patients with nonalcoholic fatty liver disease (NAFLD). We used a quantitative method based on the hepatic volume acquired from gadoxetate disodium-enhanced (Gd-EOB-DTPA-enhanced) magnetic resonance imaging (MRI) for diagnosing advanced fibrosis in patients with NAFLD. METHODS: A total of 130 patients who were diagnosed with NAFLD and underwent Gd-EOB-DTPA-enhanced MRI were retrospectively included. Histological data were available for 118 patients. Hepatic volumetric parameters, including the left hepatic lobe to right hepatic lobe volume ratio (L/R ratio), were measured. The usefulness of the L/R ratio for diagnosing fibrosis ≥F3–4 and F4 was assessed using the area under the receiver operating characteristic (AUROC) curve. Multiple regression analysis was performed to identify variables (age, body mass index, serum fibrosis markers, and histological features) that were associated with the L/R ratio. RESULTS: The L/R ratio demonstrated good performance in differentiating advanced fibrosis (AUROC, 0.80; 95% confidence interval, 0.72 to 0.88) from cirrhosis (AUROC, 0.87; 95% confidence interval, 0.75 to 0.99). Multiple regression analysis showed that only fibrosis was significantly associated with the L/R ratio (coefficient, 0.121; p<0.0001). CONCLUSIONS: The L/R ratio, which is not influenced by pathological parameters other than fibrosis, is useful for diagnosing cirrhosis in patients with NAFLD.
