Renal outcomes and clinical course of nondiabetic renal diseases in patients with type 2 diabetes.
10.3904/kjim.2013.28.5.565
- Author:
Ja Min BYUN
1
;
Cheol Hyun LEE
;
Sul Ra LEE
;
Ju Young MOON
;
Sang Ho LEE
;
Tae Won LEE
;
Chun Gyoo IHM
;
Kyung Hwan JEONG
Author Information
1. Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea. khjeong@khu.ac.kr
- Publication Type:Original Article ; Comparative Study
- Keywords:
Non-diabetic renal disease;
Diabetic nephropathies;
Diabetes mellitus, type 2
- MeSH:
Adult;
Biopsy;
Chi-Square Distribution;
Diabetes Mellitus, Type 2/*complications/diagnosis/therapy;
Diabetic Nephropathies/diagnosis/etiology;
Disease Progression;
Female;
Glomerulonephritis, IGA/complications/diagnosis;
Hospitals, University;
Humans;
Kaplan-Meier Estimate;
Kidney Diseases/*complications/diagnosis/therapy;
Kidney Failure, Chronic/diagnosis/etiology;
Logistic Models;
Male;
Middle Aged;
Multivariate Analysis;
Odds Ratio;
Prognosis;
Retrospective Studies;
Risk Factors;
Time Factors
- From:The Korean Journal of Internal Medicine
2013;28(5):565-572
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: In several recent studies, renal biopsies in patients with type 2 diabetes and renal disease have revealed a heterogeneous group of disease entities. Our aim was to study the prognosis and clinical course of nondiabetic renal disease (NDRD) and to determine risk factors for NDRD in patients with type 2 diabetes. METHODS: Renal biopsy reports of 110 patients with type 2 diabetes who were seen at Kyung Hee University Medical Center and Kyung Hee University Hospital at Gangdong, Seoul, Korea between January 2000 and December 2011 were retrospectively analyzed. RESULTS: Of 110 patients with type 2 diabetes, 41 (37.3%) had diabetic nephropathy (DN), 59 (53.6%) had NDRD, and 10 (9.1%) had NDRD superimposed on DN. Immunoglobulin A nephropathy (43.5%) was the most common NDRD. Patients with NDRD had a shorter duration of diabetes, lower frequency of diabetic retinopathy, and better renal outcomes, which might have resulted from the use of aggressive disease-specific treatments such as steroids and immunosuppressants in patients with NDRD. CONCLUSIONS: Compared with DN, NDRD was associated with better renal outcomes in patients with type 2 diabetes, as evidenced by a higher cumulative renal survival rate and lower rate of end-stage renal disease (ESRD). Shorter duration of diabetes and absence of retinopathy were independent predictors of NDRD in patients with type 2 diabetes and renal involvement. Renal biopsy is recommended for patients with type 2 diabetes and risk factors for NDRD, to obtain an accurate diagnosis, prompt initiation of disease-specific treatment, and ultimately better renal outcomes with the avoidance of ESRD.
