Antioxidant Vitamin Supplementation and Levels of Circulating Cellular Adhesion Molecules.
- Author:
Kyung Eun SONG
1
;
Shung Chul CHAE
;
Jae Eun JUN
;
Wee Hyun PARK
;
Byung Yeol CHUN
;
Hyo Jee JOUNG
;
Young Sun CHOI
;
Sung Hee CHO
Author Information
1. Department of Clinical Pathology, School of Medicine, Kyungpook National University, Taegu, Korea.
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Atherosclerosis;
Oxidative modification;
Antioxidant vitamin;
Cellular adhesion molecules;
Antioxidative enzyme;
Double-blind placebo-controlled trial
- MeSH:
Antioxidants;
Ascorbic Acid;
Atherosclerosis;
beta Carotene;
Catalase;
E-Selectin;
Erythrocytes;
Glutathione Peroxidase;
Humans;
Intercellular Adhesion Molecule-1;
Selenium;
Superoxide Dismutase;
Vascular Cell Adhesion Molecule-1;
Vitamin E;
Vitamins*
- From:Korean Journal of Clinical Pathology
2001;21(3):176-182
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The oxidative modification of lipids and the endothelial expression of adhesion molecules are key events in the pathogenesis of atherosclerosis. The appropriate antioxidants that protected and slowed the progression of the disease were reported. We measured the antioxidant enzyme activities and the levels of soluble cellular adhesion molecules in order to evaluate whether antioxidant vitamin supplementation affected the oxidative changes and the expression of cellular adhesion molecules. METHODS: Seventy-seven patients participated in a randomized, double blind, placebo-controlled trial. The test group (38 patients) was given antioxidant vitamin doses including a daily dose of vitamin C 500 mg, beta-carotene 15 mg, vitamin E 400 IUs, and selenium 50 microgram, The control group (44 patients) received placeboes for three months. We measured the vitamin serum levels, intercellular adhesion molecules-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin and activities of erythrocyte enzymes such as superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPX) before and at 3 months after supplementation. RESULTS: After supplementation, the serum vitamin levels increased significantly (P<0.05) and the activity of the erythrocyte SOD significantly increased by 0.85 unit/mg hemoglobin (P<0.05) in the test group. Soluble ICAM-1, VCAM-1 and E-selectin levels did not change significantly in the test group after supplementation. CONCLUSIONS: These results suggest that the antioxidant vitamin supplementation may affect erythrocyte SOD activity, but not soluble cellular adhesion molecule levels.
