Aberrant Thalamocortical Synchrony Associated with Behavioral Manifestations in Git1-/- Mice.
- Author:
Won MAH
1
Author Information
- Publication Type:Original Article
- Keywords: ADHD; GIT1; Thalamic oscillation; Coherence
- MeSH: Amphetamine; Animals; Ethosuximide; Mice*; Models, Animal; Thalamus
- From:Experimental Neurobiology 2015;24(2):126-132
- CountryRepublic of Korea
- Language:English
- Abstract: Cross-talk between the thalamus and cortex has been implicated in attention but its pathogenic role in attention-deficit/hyperactivity disorder (ADHD) remains unknown. Here, I demonstrate that Git1-/- mice, previously proposed as an animal model for ADHD, show abnormal theta oscillation in the thalamus. Multi-electrode recordings revealed that Git1-/- mice have hyper-synchrony of neural activities between the thalamus and cortex. The abnormal thalamic oscillation and thalamocortical synchrony in Git1-/- mice were markedly reduced by amphetamine. In addition, ethosuximide ameliorates abnormal thalamic oscillation and ADHD-like hyperactivity shown in Git1-/- mice. My study suggests critical roles of GIT1 and thalamocortical neural circuitry in ADHD.
