Serum amyloid A inhibits dendritic cell differentiation by suppressing GM-CSF receptor expression and signaling.
- Author:
Ji Cheol KIM
1
;
Young Su JUNG
;
Ha Young LEE
;
Joon Seong PARK
;
Yoe Sik BAE
Author Information
- Publication Type:Original Article
- MeSH: Dendritic Cells*; Granulocyte-Macrophage Colony-Stimulating Factor*; Interleukin-4; Receptors, Formyl Peptide; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor*; Serum Amyloid A Protein*; Toll-Like Receptors
- From:Experimental & Molecular Medicine 2017;49(8):e369-
- CountryRepublic of Korea
- Language:English
- Abstract: In this study, we report that an acute phase reactant, serum amyloid A (SAA), strongly inhibits dendritic cell differentiation induced by GM-CSF plus IL-4. SAA markedly decreased the expression of MHCII and CD11c. Moreover, SAA decreased cell surface GM-CSF receptor expression. SAA also decreased the expression of PU.1 and C/EBPα, which play roles in the expression of GM-CSF receptor. This inhibitory response by SAA is partly mediated by the well-known SAA receptors, Toll-like receptor 2 and formyl peptide receptor 2. Taken together, we suggest a novel insight into the inhibitory role of SAA in dendritic cell differentiation.
