The Effectiveness of Green Tea or Green Tea Extract on Insulin Resistance and Glycemic Control in Type 2 Diabetes Mellitus: A Meta-Analysis.
10.4093/dmj.2017.41.4.251
- Author:
Jinyue YU
1
;
Peige SONG
;
Rachel PERRY
;
Chris PENFOLD
;
Ashley R COOPER
Author Information
1. Division of Medicine, School of life and Medical Science, University College London, London, UK.
- Publication Type:Meta-Analysis ; Review
- Keywords:
Diabetes mellitus, type 2;
Glycemic control;
Green tea;
Insulin resistance;
Meta-analysis
- MeSH:
Biomarkers;
Diabetes Mellitus;
Diabetes Mellitus, Type 2*;
Fasting;
Glucose;
Hemoglobin A, Glycosylated;
Insulin Resistance*;
Insulin*;
Tea*
- From:Diabetes & Metabolism Journal
2017;41(4):251-262
- CountryRepublic of Korea
- Language:English
-
Abstract:
Green tea or green tea extract (GT/GTE) has been demonstrated to reduce insulin resistance and improve glycemic control. However, evidence for this health beneficial effect is inconsistent. This systematic review evaluated the effect of GT/GTE on insulin resistance and glycemic control in people with pre-diabetes/type 2 diabetes mellitus (T2DM). Ovid MEDLINE, Embase, AMED, Web of Science, and the Cochrane Library were searched up to April 2017 for randomised controlled trials of participants with pre-diabetes or T2DM, where the intervention was GT/GTE. Meta-analysis was performed to assess the standardised mean difference (SMD) in biomarkers of insulin resistance and glycemic control between GT/GTE and placebo groups. Six studies (n=382) were pooled into random-effects meta-analysis. Overall, no differences were found between GT/GTE and the placebo for glycosylated hemoglobin (HbA1c: SMD, −0.32; 95% confidence interval [CI], −0.86 to 0.23), homeostatic model assessment for insulin resistance (HOMA-IR: SMD, 0.10; 95% CI, −0.17 to 0.38), fasting insulin (SMD, −0.25; 95% CI, −0.64 to 0.15), and fasting glucose (SMD, −0.10; 95% CI, −0.50 to 0.30). No evidence support the consumption of GT/GTE could reduce the levels of HbA1c, HOMA-IR, fasting insulin, or fasting glucose in people with pre-diabetes/T2DM. However, the studies included were small and of varying quality.
