A case of primary amelanotic melanoma of the vagina.
- Author:
Mi Hwa PARK
1
;
You Jung HAN
;
Young PARK
;
Jong Chul BAEK
;
Ji Kwon PARK
;
Jae Gun SUNWOO
;
Jong Hak LEE
;
Won Young PAIK
Author Information
1. Department of Obstetrics and Gynecology, Gyeongsang National University, Jinju, Korea. wypaik@gnu.ac.kr
- Publication Type:Case Report
- Keywords:
Amelanotic melanoma;
Vagina;
Immunohistochemistry
- MeSH:
Accounting;
Female;
Humans;
Immunohistochemistry;
Melanins;
Melanoma;
Melanoma, Amelanotic;
Peripheral Nerves;
S100 Proteins;
Vagina
- From:Korean Journal of Obstetrics and Gynecology
2009;52(8):877-882
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Primary malignant melanoma of the vagina is extremely rare, accounting for 3% of all primary malignant tumor of the vagina and 0.3~1% of all malignant melanomas in the female. The amelanotic melanoma of the vagina showing no melanin granules on histological examination is exceedingly rare, accounting for only about 10% of all melanoma of the vagina. The amelanotic melanoma of the vagina is often difficult to differentiate from non-epithelial malignant tumor because of the minimal number of melanin granules. We describe a case of primary amelanotic melanoma of the vagina, which was initially suspected to be a non-epithelial malignant tumor, especially malignant peripheral nerve sheath tumor (MPNST), but was correctly diagnosed by HMB-45 antibody and S-100 protein immunohistochemical staining. So we present this case with a brief review of literature.
