Intravenous albumin for the prevention of contrast-induced nephropathy in patients with liver cirrhosis and chronic kidney disease undergoing contrast-enhanced CT.
- Author:
Heejung CHOI
1
;
Yoonjung KIM
;
Soo Min KIM
;
Junam SHIN
;
Hye Ryoun JANG
;
Jung Eun LEE
;
Wooseong HUH
;
Yoon Goo KIM
;
Ha Young OH
;
Dae Joong KIM
Author Information
1. Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. daejoongsmc.kim@samsung.com
- Publication Type:Original Article
- Keywords:
Albumin;
Chronic kidney disease;
Contrast-induced nephropathy;
Liver cirrhosis
- MeSH:
Body Weight;
Creatinine;
Diabetes Mellitus;
Glomerular Filtration Rate;
Humans;
Incidence;
Liver;
Liver Cirrhosis;
Renal Insufficiency, Chronic;
Retrospective Studies;
Sodium Bicarbonate
- From:Kidney Research and Clinical Practice
2012;31(2):106-111
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The purpose of this study was to evaluate the incidence of contrast-induced nephropathy (CIN), and the effect of intravenous albumin for prophylaxis of CIN in patients with liver cirrhosis (LC) and chronic kidney disease (CKD). METHODS: We conducted a retrospective study of 81 subjects with LC and CKD (estimated glomerular filtration rate (eGFR)<60mL/min/1.73m2) who underwent contrast-enhanced computed tomography (CT). Patients received either isotonic sodium bicarbonate solution (3mL/kg for 1h before CT and 1mL/kg/h for 6h after CT) or albumin (20% albumin, 25mL for 1h before CT and 75mL for 6h after CT). CIN was defined as an increase of > or =25% or > or =0.5mg/dL in serum creatinine level. RESULTS: Overall, CIN developed in three patients (3.7%). Of the 81 subjects, 43 received sodium bicarbonate solution and 38 received albumin. Both groups were comparable with regard to age, sex, diabetes mellitus, and baseline eGFR. The albumin group showed a significantly poorer liver function profile. CIN incidence did not differ significantly between the groups: it occurred in one (2.3%) of the 43 subjects receiving sodium bicarbonate and two (5.3%) of the 38 subjects receiving albumin (P=0.6). However, the albumin group showed a significantly smaller increase in body weight (P=0.03). CONCLUSION: The incidence of CIN in patients with LC and CKD undergoing contrast-enhanced CT after preventive measures was relatively low. The incidence of CIN was not significantly different between sodium bicarbonate and albumin groups.
