A Case of Distal Renal Tubular Acidosis by Damage of H+-ATPase Pump after Paraquat Intoxication.
- Author:
Hyo Wook GIL
1
;
Min Soo SONG
;
Jong Oh YANG
;
Eun Young LEE
;
Sae Yong HONG
;
Jin KIM
Author Information
1. Department of Internal Medicine and Institute of Pesticide Poisoning, Soonchunhyang University, Cheonan Hospital, Cheonan, Korea. eylee@sch.ac.kr
- Publication Type:Case Report
- Keywords:
Distal renal tubular acidosis;
Paraquat;
H+-ATPase
- MeSH:
Acidosis, Renal Tubular*;
Amphotericin B;
Biopsy;
Glomerular Filtration Rate;
Ifosfamide;
Lithium Carbonate;
Necrosis;
Paraquat*;
Proton Pumps;
Toluene
- From:Korean Journal of Nephrology
2004;23(4):685-689
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Distal Renal tubular acidosis is characterized by tubular dysfunction with a decrease in net H+-secretion in the collecting tubules regardless of normal glomerular filtration rate. It classified into primary and secondary form. The causes of secondary form could be many drugs such as amphotericin B, toluene, lithium carbonate, ifosfamide, but paraquat has not been reported. The mechanism of renal damage by paraquat has not be fully comprehensive but it is thought that paraquat causes damage to renal proximal tubules and clinically induces acute tubular necrosis. Our case demonstrated that immunohistochemical staining of renal biopsy specimen with anti H+-ATPase antibody showed absence of proton pump in collecting duct. Thus a case of distal renal tubular acidosis in association with paraquat intoxication is reported with a review of literatures.
