Association between dietary flavanones intake and lipid profiles according to the presence of metabolic syndrome in Korean women with type 2 diabetes mellitus.
- Author:
Ji Soo OH
1
;
Hyesook KIM
;
Aswathy VIJAYAKUMAR
;
Oran KWON
;
Young Ju CHOI
;
Kap Bum HUH
;
Namsoo CHANG
Author Information
- Publication Type:Original Article
- Keywords: Apolipoprotein; flavanones; metabolic syndrome; T2DM
- MeSH: Apolipoproteins; Apolipoproteins B; Cholesterol; Cross-Sectional Studies; Diabetes Mellitus, Type 2*; Female; Flavanones*; Humans; Korea; Linear Models; Logistic Models; Odds Ratio; Risk Factors; Seoul
- From:Nutrition Research and Practice 2016;10(1):67-73
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/OBJECTIVES: This study was aimed at examining the association between dietary flavanones intake and lipid profiles according to the presence of metabolic syndrome (MetS) in Korean women with type 2 diabetes mellitus (T2DM). SUBJECTS/METHODS: A cross-sectional analysis was performed among 502 female T2DM patients (non-MetS group; n = 129, MetS group; n = 373) who were recruited from the Huh's Diabetes Clinic in Seoul, Korea between 2005 and 2011. The dietary intake was assessed by a validated semi-quantitative food frequency questionnaire (FFQ) and the data was analyzed using the Computer Aided Nutritional Analysis program (CAN-Pro) version 4.0 software. The intake of flavanones was estimated on the basis of the flavonoid database. RESULTS: In the multiple linear regression analysis after adjustment for confounding factors, daily flavanones intake was negatively associated with CVD risk factors such as total cholesterol, LDL-cholesterol, and apoB and apoB/apoA1 ratio only in the MetS group but not in the non-MetS group. Multiple logistic regression analysis revealed that the odds ratio for a higher apoB/apoA1 ratio above the median (> or = 0.74) was significantly low in the 4th quartile compared to that in the 1st quartile of dietary flavanones intake [OR: 0.477, 95% CI: 0.255-0.894, P for trend = 0.0377] in the MetS group. CONCLUSIONS: Dietary flavanones intake was inversely associated with the apoB/apoA1 ratio, suggesting a potential protective effect of flavanones against CVD in T2DM women with MetS.
