Analysis of Electrically Evoked Potential in Rabbits with Polyimide Retinal Stimulator.
- Author:
Seung Hyun KIM
1
;
Jong Mo SEO
;
Seong Joon KIM
;
Eui Tae KIM
;
Sung June KIM
;
Young Suk YU
;
Hum CHUNG
Author Information
1. Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. ysyu@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Artificial retina;
Electrical stimulation;
Evoked potential;
Light stimulation
- MeSH:
Electric Stimulation;
Evoked Potentials*;
Evoked Potentials, Visual;
Microelectrodes;
Multiple Endocrine Neoplasia Type 1;
Rabbits*;
Retina;
Retinaldehyde*
- From:Journal of the Korean Ophthalmological Society
2004;45(8):1363-1367
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Electrically evoked potential (EEP) was recorded in rabbits with polyimide-based, multichannel, microelectrode array (MEA) in their eyes, and was compared with the visual evoked potential (VEP) by flash light. METHODS: VEP was recorded under full-field flash light stimulation by 0. 6 J at 2 Hz, while EEP was recorded under electrical current stimulation of the retina by MEA. Latencies and shapes of N1, P100 and N2 in each evoked potential were compared. RESULTS: EEP was recorded in four of six rabbits. N1, P100 and N2 were observed in EEP on the electrical retina stimulation over 2.5 mA, and they resembled those of VEP. However, N1, P100 and N2 of EEP showed shorter latencies than those of VEP, by 15.1 msec (32.9%), 76.8 msec (38.3%) and 99.7 msec (60.1%) respectively. CONCLUSIONS: EEP by electrical retina stimulation with MEA was similar to VEP, indicating that MEA is suitable for the development of the artificial retina prototype. The shorter latencies of EEP should be considered in the parameters of the electrical stimulation of the retina.
