Evaluation of an Immunochromatography Assay Kit for the Detection of Antibodies to the Mycobacterium leprae-specific Phenolic Glycolipid-I Antigen.
- Author:
Jong Pill KIM
1
;
Sang Nae CHO
;
Young Hoon KO
Author Information
1. Institute for Leprosy Research, Korean Hansen Welfare Association, Korea. dr_jpkim@hotmail.com
- Publication Type:Original Article
- Keywords:
leprosy;
phenolic glycolipid-I;
immunochromatographic assay;
serodiagnosis
- MeSH:
Antibodies*;
Enzyme-Linked Immunosorbent Assay;
Immunochromatography*;
Leprosy;
Mycobacterium leprae;
Mycobacterium*;
Phenol*;
Sensitivity and Specificity;
Seroepidemiologic Studies;
Serologic Tests
- From:Korean Leprosy Bulletin
2003;36(1):27-34
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Among the many reported applications of the detection of antibodies to phenolic glycolipid-I (PGL-I) of Mycobacterium leprae, the use of seroprevalence as an indicator of the magnitude of the leprosy problem may turn out to be very useful in leprosy control programs. In order to facilitate the use of PGL-I based serology in leprosy control programs, however, a simple test system for the detection of antibodies to PGL-I has been required. For being searched the meaning of qualitative analysis for PGL-I antibodies, we examined enzyme-linked immunosorbent assay and immunochromatographic assay kit using PGL-I neoglycoconjugate antigens. The sensitivity was 91.7%, and the specificity was 78.1%.
