A Multicenter Study of Antimicrobial Susceptibility of Uropathogens Causing Acute Uncomplicated Cystitis in Woman.
- Author:
Seung Ju LEE
1
;
Yong Hyun CHO
;
Bup Wan KIM
;
Jeong Gu LEE
;
Se Il JUNG
;
Sang Don LEE
;
Sang Eun LEE
;
Min Eui KIM
;
Young Deuk CHOI
;
Joung Sik RIM
;
Bong Suck SIM
;
In Rae CHO
;
Soo Bang RYU
;
Chul Sung KIM
;
Wun Jae KIM
;
Tchun Yong LEE
Author Information
1. Department of Urology, College of Medicine, Catholic University, Korea. cyh0831@catholic.ac.kr
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Woman;
Cystitis;
Disease susceptibility
- MeSH:
Ampicillin;
Anti-Infective Agents;
Ciprofloxacin;
Coagulase;
Cystitis*;
Disease Susceptibility;
Escherichia;
Female;
Gentamicins;
Humans;
Korea;
Outpatients;
Prevalence;
Tobramycin;
Urinary Tract
- From:Korean Journal of Urology
2003;44(7):697-701
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Worldwide data shows that there is an increasing resistance among urinary tract pathogens to the first-line antimicrobial agents used in domestic areas. The objective of this study was to obtain data on the susceptibility patterns of the pathogens responsible for acute uncomplicated cystitis to currently used antimicrobial agents. MATERIALS AND METHODS: This study was carried out with the participation of fifteen hospitals in South Korea. A total of 239 isolates were obtained from female outpatients with acute uncomplicated cystitis. The antimicrobial susceptibilities to ampicillin, ampicillin/sulbactam, ciprofloxacin, gentamicin, trimethoprim/sulfamethoxazole(TMP/SMX) and tobramycin were determined by Vitek(R) antimicrobial susceptibility test systems. RESULTS: The most prevalent causative organism was Escherichia coli(79.9%), followed by coagulase negative Staphylococcus(4.2%), and a combination of other species of Enterobacteriaceae(8.2%). The mean rates of susceptibility were 35.5, 45.0, 85.7, 81.5, 62.1 and 85.3% to ampicillin, ampicillin/sulbactam, ciprofloxacin, gentamicin, TMP/ SMX and tobramycin, respectively. No significant differences were detected in the resistance rates between the results from 4 regional groups. CONCLUSIONS: The high prevalence of resistance to ampicillin, ampicillin/sulbactam, and TMP/SMX suggest these drugs would not provide adequate initial therapy, and therapies other than TMP/SMX may need to be considered. The relatively high prevalence of resistance to ciprofloxacin, compared with other countries, also requires on going surveillance to identify further changes among urinary tract isolates.
