High-Grade Prostatic Intraepithelial Neoplasia.
10.4111/kju.2012.53.5.297
- Author:
Joseph C KLINK
1
;
Ranko MIOCINOVIC
;
Cristina MAGI GALLUZZI
;
Eric A KLEIN
Author Information
1. Glickman Urologic and Kidney Institute, Cleveland, Ohio, USA. klinkj@ccf.org
- Publication Type:Review
- Keywords:
HGPIN;
High grade prostatic intraepithelial neoplasia;
Prostate biopsy;
Prostate cancer
- MeSH:
Adenocarcinoma;
Biopsy;
Mass Screening;
Prostate;
Prostate-Specific Antigen;
Prostatic Intraepithelial Neoplasia;
Prostatic Neoplasms
- From:Korean Journal of Urology
2012;53(5):297-303
- CountryRepublic of Korea
- Language:English
-
Abstract:
High-grade prostatic intraepithelial neoplasia (HGPIN) has been established as a precursor to prostatic adenocarcinoma. HGPIN shares many morphological, genetic, and molecular signatures with prostate cancer. Its predictive value for the development of future adenocarcinoma during the prostate-specific antigen screening era has decreased, mostly owing to the increase in prostate biopsy cores. Nevertheless, a literature review supports that large-volume HGPIN and multiple cores of involvement at the initial biopsy should prompt a repeat biopsy of the prostate within 1 year. No treatment is recommended for HGPIN to slow its progression to cancer.
