3-Hydroxy-4,7-megastigmadien-9-one, Isolated from Ulva pertusa Kjellman, Inhibits LPS-Induced Inflammatory Response by Down-Regulating Mitogen-Activated Protein Kinase and NF-κB Pathways.
10.4167/jbv.2016.46.3.167
- Author:
Irshad ALI
1
;
Zahid MANZOOR
;
Young Sang KOH
Author Information
1. Department of Microbiology and Immunology, School of Medicine and Brain Korea 21 PLUS Program, Jeju National University, Jeju, Korea. yskoh7@jejunu.ac.kr
- Publication Type:Brief Communication
- Keywords:
Ulva pertusa Kjellman;
Anti-inflammatory activity;
3-Hydroxy-4,7-megastigmadien-9-one
- MeSH:
Dendritic Cells;
Interleukin-12;
Interleukin-6;
Phosphorylation;
Protein Kinases*;
Ulva*
- From:Journal of Bacteriology and Virology
2016;46(3):167-172
- CountryRepublic of Korea
- Language:English
-
Abstract:
In the present study we evaluated the anti-inflammatory potential of 3-hydroxy-4,7-megastigmadien-9-one (Comp) isolated from Ulva pertusa Kjellman, in LPS-stimulated bone marrow-derived dendritic cells (BMDCs). Comp treatment exhibited strong dose dependent inhibition of IL-12 p40 and IL-6 cytokine production with IC₅₀ values of 7.85 ± 0.32 and 7.86 ± 0.18, respectively in LPS-stimulated BMDCs. Treatment of Comp inhibited MAPKs and NF-κB pathways in LPS-stimulated BMDCs by inhibiting the phosphorylation of ERK1/2, JNK1/2, p38 and IκB. Thus, these results suggest that Comp have a significant anti-inflammatory property and affirm further studies concerning the potentials of Comp for medicinal use.
