Stem Cell Therapy for Neonatal Disorders: Prospects and Challenges.
10.3349/ymj.2017.58.2.266
- Author:
Yun Sil CHANG
1
;
So Yoon AHN
;
Sein SUNG
;
Won Soon PARK
Author Information
1. Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. wonspark@skku.edu
- Publication Type:Review
- Keywords:
Mesenchymal stem cells;
bronchopulmonary dysplasia;
intraventricular hemorrhage;
hypoxic ischemic encephalopathy;
newborn
- MeSH:
Bronchopulmonary Dysplasia;
Hemorrhage;
Humans;
Hypoxia-Ischemia, Brain;
Infant, Newborn;
Mesenchymal Stromal Cells;
Mortality;
Stem Cells*
- From:Yonsei Medical Journal
2017;58(2):266-271
- CountryRepublic of Korea
- Language:English
-
Abstract:
Despite recent advances in neonatal medicine, neonatal disorders, such as bronchopulmonary dysplasia and intraventricular hemorrhage in preterm neonates and hypoxic ischemic encephalopathy in term neonates, remain major causes of mortality and morbidities. Promising preclinical research results suggest that stem cell therapies represent the next breakthrough in the treatment of currently intractable and devastating neonatal disorders with complex multifactorial etiologies. This review focuses primarily on the potential role of stem cell therapy in the above mentioned neonatal disorders, highlighting the results of human clinical trials and the challenges that remain to be addressed for their safe and successful translation into clinical care of newborn infants.
