Serum Chemerin Levels are Associated with Visceral Adiposity, Independent of Waist Circumference, in Newly Diagnosed Type 2 Diabetic Subjects.
10.3349/ymj.2017.58.2.319
- Author:
Dae Young CHEON
1
;
Jun Goo KANG
;
Seong Jin LEE
;
Sung Hee IHM
;
Eun Jig LEE
;
Moon Gi CHOI
;
Hyung Joon YOO
;
Chul Sik KIM
Author Information
1. Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea. ironeat@gmail.com
- Publication Type:Original Article
- Keywords:
Chemerin;
visceral fat;
type 2 diabetes mellitus
- MeSH:
Adiposity*;
Body Mass Index;
C-Reactive Protein;
Cholesterol;
Diabetes Mellitus, Type 2;
Homeostasis;
Insulin;
Insulin Resistance;
Intra-Abdominal Fat;
Linear Models;
Lipoproteins;
Obesity;
Triglycerides;
Waist Circumference*
- From:Yonsei Medical Journal
2017;58(2):319-325
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Chemerin has been suggested to be linked to insulin resistance and type 2 diabetes mellitus (T2DM). However, the relationship between visceral adiposity and chemerin levels remains unclear in subjects with T2DM. In this study, we investigated the relationship between serum chemerin levels and visceral adiposity. MATERIALS AND METHODS: This study included 102 subjects newly diagnosed with T2DM. The relationships between serum chemerin levels and clinical and biochemical parameters were examined. Multiple linear regression analysis was performed to determine the predictable factors of serum chemerin levels. RESULTS: Serum chemerin levels showed significant positive correlations with body mass index (BMI), waist circumference (WC), visceral fat thickness (VFT), insulin levels, the homeostasis model assessment of insulin resistance, and levels of triglycerides (log-transformed) and high-sensitivity C-reactive protein, while showing significant negative correlations with high-density lipoprotein cholesterol. After adjusting for BMI and WC, VFT showed a significant relationship with serum chemerin levels (r=0.222, p=0.027). Moreover, VFT was an independent predictive factor of serum chemerin levels (β=0.242, p=0.041). CONCLUSION: We demonstrated that chemerin is linked to metabolic syndrome components. Moreover, serum chemerin levels were associated significantly with obesity, especially visceral adipose tissue, in subjects with T2DM.
