Parameters of Glucose and Lipid Metabolism Affect the Occurrence of Colorectal Adenomas Detected by Surveillance Colonoscopies.
10.3349/ymj.2017.58.2.347
- Author:
Nam Hee KIM
1
;
Jung Yul SUH
;
Jung Ho PARK
;
Dong Il PARK
;
Yong Kyun CHO
;
Chong Il SOHN
;
Kyuyong CHOI
;
Yoon Suk JUNG
Author Information
1. Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. ys810.jung@samsung.com
- Publication Type:Original Article
- Keywords:
Colorectal adenoma;
surveillance;
glucose metabolism;
dyslipidemia
- MeSH:
Adenoma*;
Apolipoproteins;
Colonoscopy*;
Dyslipidemias;
Fasting;
Follow-Up Studies;
Glucose*;
Homeostasis;
Insulin;
Insulin Resistance;
Life Style;
Lipid Metabolism*;
Longitudinal Studies;
Proportional Hazards Models;
Triglycerides
- From:Yonsei Medical Journal
2017;58(2):347-354
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Limited data are available regarding the associations between parameters of glucose and lipid metabolism and the occurrence of metachronous adenomas. We investigated whether these parameters affect the occurrence of adenomas detected on surveillance colonoscopy. MATERIALS AND METHODS: This longitudinal study was performed on 5289 subjects who underwent follow-up colonoscopy between 2012 and 2013 among 62171 asymptomatic subjects who underwent an initial colonoscopy for a health check-up between 2010 and 2011. The risk of adenoma occurrence was assessed using Cox proportional hazards modeling. RESULTS: The mean interval between the initial and follow-up colonoscopy was 2.2±0.6 years. The occurrence of adenomas detected by the follow-up colonoscopy increased linearly with the increasing quartiles of fasting glucose, hemoglobin A1c (HbA1c), insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and triglycerides measured at the initial colonoscopy. These associations persisted after adjusting for confounding factors. The adjusted hazard ratios for adenoma occurrence comparing the fourth with the first quartiles of fasting glucose, HbA1c, insulin, HOMA-IR, and triglycerides were 1.50 [95% confidence interval (CI), 1.26–1.77; p(trend)<0.001], 1.22 (95% CI, 1.04–1.43; p(trend)=0.024), 1.22 (95% CI, 1.02–1.46; p(trend)=0.046), 1.36 (95% CI, 1.14–1.63; p(trend)=0.004), and 1.19 (95% CI, 0.99–1.42; p(trend)=0.041), respectively. In addition, increasing quartiles of low-density lipoprotein-cholesterol and apolipoprotein B were associated with an increasing occurrence of adenomas. CONCLUSION: The levels of parameters of glucose and lipid metabolism were significantly associated with the occurrence of adenomas detected on surveillance colonoscopy. Improving the parameters of glucose and lipid metabolism through lifestyle changes or medications may be helpful in preventing metachronous adenomas.
