Chromosime Analysis from Chorionic Villi Samples in Recurrent Sponataneous Abortion.
- Author:
Tae Wook YOO
;
Jung Hye HWANG
;
Moon Il PARK
;
Sung Ro CHUNG
;
Yeun Young HWANG
;
Sung Han SHIM
;
Chun Geun LEE
;
Yool Hee CHO
- Publication Type:Original Article
- Keywords:
Karyotype;
Conceptus;
Chorionic villi sampling;
Recurrent abortion
- MeSH:
Abortion, Habitual;
Adult;
Chorion*;
Chorionic Villi Sampling;
Chorionic Villi*;
Chromosome Aberrations;
Chromosomes, Human, Pair 16;
Female;
Gestational Age;
Humans;
Incidence;
Karyotype;
Monosomy;
Mosaicism;
Pregnancy;
Tetraploidy;
Trisomy
- From:Korean Journal of Perinatology
1997;8(4):408-413
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Recurrent abortion has been defined as the occurrence of three or more clinically recognized pregnancy loss before 20 weeks and it occurs in 1% of women. The chromosomal abnormalities of abortuses have been suggested as the most common causes of recurrent abortion. We have studied the incidence of chromosomal abnormalities in 57 patients with recurrent abortion using the chorionic villi samples. Of the 57 abortuses analysed, 32 (56.1%) had chromosomal abnormalities. Trisomy was predominant (23 cases, 40.4%), followed by mosaicism 3 (5.2%), tetraploidy 2 (3.5%), monosomy 2 (3.5%), and structural anomaly 1 (1.8%). Trisomy for the chromosome 16 was most prevalent among trisomies. The incidence of trisomy was positively related to matemal age above 35 year-old. But there is not statistically significant. And there are no correlation between gestational age and chromosomal abnormalities. In conclusion, the incidence of chromosomal abnormalities of recurrent abortuses was 56.1% which was similar to that of the other reports. This means that the analysis of karyotype of chorionic villi, as the first test to investigate the cause of recurrent abortion, may be not useful, however, it will require further.
