An Experimental Study on the Effect of Transfusion and Various Fluid Therapy upon Blood Coagulability in Acute Blood Loss .
- Author:
Kwang Won YUM
1
;
Ho Jo CHANG
;
Kwang Woo KIM
;
II Young KWAK
Author Information
- Publication Type:Original Article
- MeSH: Animals; Bleeding Time; Blood Platelets; Blood Sedimentation; Dextrans; Dogs; Fluid Therapy*; Hemodilution; Molecular Weight; Platelet Count
- From:Korean Journal of Anesthesiology 1972;5(1):1-8
- CountryRepublic of Korea
- Language:Korean
- Abstract: Fourty-eight mongrel dogs were bled to half the level of their control aystolic blood pressures and infused with Hartmanns solution, low molecular weight dextran, whole blood, or with Hartmann's solution+low molecular weight dextran (1:1 or 1:3) in the amount equivalent to the blood loss. Bleeding time, coagulation time, platelet count and erythrocyte sedimentation rate were examined 6 hours and 24 hours after the completion of infusion. The results are as follows: 1) No changes in blood coagulability other than due to hemodilution were observed in dogs infused with Hartmann's solution, whole blood, or 1:1 Hartmann's solution+low molecular weight dextran. 2) Significant changes in blood coagulability were noted, however, in dogs infused with low molecular weight dextran alone or 1:3 Hartmann's solution+low molseular weight dextran. These changes seem to be related rather to decreased platelet function than to the decease in platelet number.
