A Case of Gastric Schwannoma.
10.5230/jkgca.2002.2.2.101
- Author:
Jae Hyuck CHOI
1
;
Weon Young CHANG
;
Jin Suk HUH
;
Jae Hyung NOH
;
Tae Sung SOHN
;
Sung Ho CHOI
;
Sung KIM
;
Yong Il KIM
Author Information
1. Department of Surgery, Gastrointestinal Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. jhnoh@smc.samsung.co.kr
- Publication Type:Case Report
- Keywords:
Schwannoma;
Stomach;
Submucosal tumor
- MeSH:
Actin Cytoskeleton;
Actins;
Adult;
Basement Membrane;
Desmin;
Female;
Glial Fibrillary Acidic Protein;
Humans;
Leiomyoma;
Lymphocytes;
Muscle, Smooth;
Neurilemmoma*;
S100 Proteins;
Stomach;
Vimentin
- From:Journal of the Korean Gastric Cancer Association
2002;2(2):101-104
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Schwannoma of the stomach is a rare controversial neoplasm which requires extensive studies to clarify its nature as a stromal tumor or leiomyoma. We describe the pathologic, immunohistochemical, and ultrastructural characteristics of schwannoma of the stomach in a 33-year-old woman. The tumor was a well-circumscribed submucosal mass located in the posterior wall of the midbody of the stomach. Microscopically, the cells were made up of fasciculating bundles of spindle cells featured with peripheral lymphoid cell cuffing. The tumor cells revealed a diffuse, strong immunoreactivity to S-100 protein and vimentin, but were negative to desmin and smooth muscle actin. They also had a focal positive reaction to glial fibrillary acidic protein. Ultrastructurally, many tumor cells showed a number of thin, elongated and interdigitating dendritic-cell-like processes, distinctly uniformed basal laminae, frequent cellular attachments, and microfilaments. These findings support the schwannian nature of the tumor.
