Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression in Thyroid Neoplasms and Their Clinicopathological Correlation.
10.3346/jkms.2006.21.6.1064
- Author:
Kyung Hee KIM
1
;
Seong Ho KIM
;
Seok Hyung KIM
;
Jong Ho BACK
;
Mee Ja PARK
;
Jin Man KIM
Author Information
1. Department of Pathology and Molecular Medicine, Eulji University School of Medicine, Daejeon, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Thyroid Neoplasms;
Cyclooxygenase 2;
Nitric Oxide Synthase Type II
- MeSH:
Tumor Markers, Biological/*analysis;
Tissue Distribution;
Thyroid Neoplasms/*diagnosis/*enzymology;
Statistics;
Sensitivity and Specificity;
Reproducibility of Results;
Nitric Oxide Synthase Type II/*analysis;
Neoplasm Proteins/*analysis;
Middle Aged;
Male;
Humans;
Gene Expression Profiling;
Female;
Cyclooxygenase 2/*analysis;
Aged;
Adult
- From:Journal of Korean Medical Science
2006;21(6):1064-1069
- CountryRepublic of Korea
- Language:English
-
Abstract:
To evaluate the expressions of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in thyroid neoplasms in a Korean population, we studied a total of 154 cases: papillary carcinoma of classical type (PTC), 86; follicular adenoma (FA), 21; follicular carcinoma (FC), 35; medullary carcinoma (MC), 3; undifferentiated carcinoma (UC), 5; and Hurthle cell neoplasm (HN), 4. Using immunohistochemical staining, COX-2 expression was detected in 62 (72.1%) PTC specimens, 5 (23.8%) FA specimens, 10 (28.6%) FC specimens, 0 (0.0%) MC specimens, 1 (20.0%) UC specimen, and 3 (75%) HN specimens. iNOS expression was detected in 66 (76.7%) PTC specimens, 4 (19.0%) FA specimens, 13 (37.1%) FC specimens, 0 (0.0%) MC specimens, 3 (60.0%) UC specimens, and 4 (100%) HN specimens. The results showed that COX-2 and iNOS were frequently expressed in the PTC and HN specimens, and iNOS was more frequently overexpressed in the FC specimens than in the FA specimens. In PTC, COX-2 and iNOS were significantly overexpressed in patients over 45 yr of age (p=0.029, p=0.041), and iNOS expression was increased in patients with a large primary tumor (p=0.028). These results suggest that the upregulation of COX-2 and iNOS may contribute to the tumor progression of thyroid gland, particularly in PTC and HN, and iNOS may play an adjuvant role during the tumor progression of FC.
