A Case of Hypersensitivity Syndrome to Both Vancomycin and Teicoplanin.
10.3346/jkms.2006.21.6.1108
- Author:
Hyouk Soo KWON
1
;
Yoon Seok CHANG
;
Yi Yeong JEONG
;
Sang Min LEE
;
Woo Jung SONG
;
Hong Bin KIM
;
Yoon Keun KIM
;
Sang Heon CHO
;
You Young KIM
;
Kyung Up MIN
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongun-dong Chongno-gu, Seou, Korea. drmin@snu.ac.kr
- Publication Type:Case Report ; Research Support, Non-U.S. Gov't
- Keywords:
Drug Hypersensitivity;
Patch Tests;
Vancomycin;
Teicoplanin;
linezolid
- MeSH:
Vancomycin/*adverse effects;
Teicoplanin/*adverse effects;
Syndrome;
Middle Aged;
Male;
Humans;
Drug Hypersensitivity/*diagnosis/*etiology;
Drug Combinations
- From:Journal of Korean Medical Science
2006;21(6):1108-1110
- CountryRepublic of Korea
- Language:English
-
Abstract:
Drug hypersensitivity syndrome to both vancomycin and teicoplanin has not been previously reported. We describe here a 50-yr-old male patient with vertebral osteomyelitis and epidural abscess who developed hypersensitivity syndrome to both vancomycin and teicoplanin. Skin rash, fever, eosinophilia, interstitial pneumonitis, and interstitial nephritis developed following the administration of each drug, and resolved after withdrawing the drugs and treating with high dose corticosteroids. The vertebral osteomyelitis was successfully treated with 6-week course of linezolid without further complications. Skin patch tests for vancomycin and teicoplanin was done 2 months after the recovery; a weak positive result for vancomycin (10% aq.,+at D2 and +at D4 with erythema and vesicles; ICDRG scale), and a doubtful result for teicoplanin (4% aq.-at D2 and+/-at D4 with macular erythema; ICDRG scale). We present this case to alert clinicians to the hypersensitivity syndrome that can result from vancomycin and teicoplanin, with possible cross-reactivity, which could potentially be life-threatening.
