A Case of Renal Crisis in a Korean Scleroderma Patient with Anti-RNA polymerase I and III Antibodies.
10.3346/jkms.2006.21.6.1121
- Author:
Eun Ha KANG
1
;
Churl Hyun IM
;
Su Ho KIM
;
Jae Rak CHUNG
;
Eun Young LEE
;
Dong Jo KIM
;
Eun Bong LEE
;
Yeong Wook SONG
Author Information
1. Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. ysong@snu.ac.kr
- Publication Type:Case Report ; Research Support, Non-U.S. Gov't
- Keywords:
Scleroderma, Systemic;
Autoantibodies;
RNA Polymerase III;
RNA Polymerase I
- MeSH:
Scleroderma, Systemic/*complications/enzymology/*immunology;
RNA Polymerase III/*immunology;
RNA Polymerase I/*immunology;
Korea;
Kidney Failure, Acute/*complications/enzymology/*immunology;
Humans;
Female;
Critical Care;
Autoantibodies/*blood;
Aged
- From:Journal of Korean Medical Science
2006;21(6):1121-1123
- CountryRepublic of Korea
- Language:English
-
Abstract:
Scleroderma (SSc) renal crisis has been reported to be associated with anti-RNA polymerase I and III (RNAP I/III) antibodies in Caucasians and the Japanese. However, no report is available for Korean SSc patients. Here, we describe the case of a 65-yr-old female SSc patient who developed renal crisis and whose serum contained anti-RNAP I/III antibodies. She was finally diagnosed as having diffuse cutaneous SSc based on skin thickening proximal to the elbows and knees. Sudden hypertension, oliguria, and pulmonary edema were features of her renal crisis. Despite the use of captopril and adequate blood pressure control, her renal function deteriorated. Subsequent renal biopsy findings showed severe fibrinoid necrosis with luminal obliteration in interlobar arteries and arterioles consistent with SSc renal crisis. Serum anti-RNAP I/III antibodies were detected by radioimmunoprecipitation. This is the first report of a renal crisis in a Korean SSc patient with RNAP I/III antibodies.
