Risk factors of gastrointestinal bleeding for end-stage renal disease patients.
- Author:
Hyung Jung OH
1
;
Seung Jun KIM
;
Sun Young PARK
;
Dong Eun YOO
;
Han Sung LEE
;
Nam Su KU
;
Ji Ae MOON
;
Dong Ki KIM
;
Tae Hee LEE
;
Sung Jin MOON
;
Seung Heok HAN
;
Jeung Eun LEE
;
Hoon Young CHOI
;
Dae Suk HAN
;
Shin Wook KANG
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. kswkidney@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
End-stage renal disease;
Gastrointestinal bleeding;
Coronary arterial occlusive disease;
Nonsteroidal anti-inflammatory drug;
Serum albumin
- MeSH:
Anti-Inflammatory Agents, Non-Steroidal;
Arterial Occlusive Diseases;
Dialysis;
Heart Failure;
Hemorrhage*;
Humans;
Incidence;
Kidney Failure, Chronic*;
Logistic Models;
Mortality;
Retrospective Studies;
Risk Factors*;
Serum Albumin
- From:Korean Journal of Medicine
2007;72(6):616-624
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUDN: Gastrointestinal bleeding (GIB) is not a rare complication in end-stage renal disease (ESRD) patients on dialysis and the occurrence of GIB has also been associated with higher morbidity and mortality rates. However, reasons for the high incidence of GIB are not clear. This retrospective study was undertaken not only to analyze the clinical features of GIB but also to elucidate the independent risk factors for GIB in Korean ESRD patients. METHODS: One hundred thirty ESRD patients on dialysis at the Severance Hospital of Yonsei University College of Medicine from January 2000 to December 2005 were included in the study. The patients were divided into two groups: 65 patients with GIB (the GIB group) and 65 age-, sex-, and dialysis modality-matched patients without GIB (the C group). Clinical characteristics, medications, and laboratory findings were compared between the two groups. RESULTS: Compared to the C group, congestive heart failure (40.0% vs. 21.5%, p<0.05), coronary arterial occlusive disease (CAOD) (32.3% vs. 4.6%, p<0.005), and nonsteroidal anti-inflammatory drug (NSAID) use (18.4% vs. 1.5%, p<0.01) were significantly more common in the GIB group. The baseline serum albumin levels were significantly lower in the GIB group than in the C group (2.53+/-0.67 g/dL vs. 3.56+/-0.63 g/dL, p<0.005). Using logistic regression analysis, CAOD (OR=23.0), NSAID use (OR=12.5), and lower serum albumin levels (OR=2.9) were identified as independent risk factors for GIB (p<0.05). CONCLUSIONS: Careful attention must be paid to ESRD patients with CAOD, taking NSAIDs, or with low serum albumin levels in view of GIB.
