The Relation of Thyroid Function to Components of the Metabolic Syndrome in Korean Men and Women.
10.3346/jkms.2011.26.4.540
- Author:
Sat Byul PARK
1
;
Ho Chun CHOI
;
Nam Seok JOO
Author Information
1. Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Korea. sbpark@ajou.ac.kr
- Publication Type:Original Article
- Keywords:
Thyroid Function;
Cardiovascular Risk Factors;
Metabolic Syndrome;
Insulin Resistance
- MeSH:
Adult;
Asian Continental Ancestry Group;
Blood Glucose/analysis;
Blood Pressure;
Cholesterol, HDL/blood;
Cholesterol, LDL/blood;
Female;
Follow-Up Studies;
Humans;
Logistic Models;
Male;
Metabolic Syndrome X/*physiopathology;
Middle Aged;
Predictive Value of Tests;
Republic of Korea;
Risk Factors;
Thyroid Gland/*physiopathology;
Thyrotropin/blood;
Thyroxine/blood;
Triglycerides/blood;
Waist Circumference
- From:Journal of Korean Medical Science
2011;26(4):540-545
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study was to assess the relation of thyroid dysfunction to metabolic syndrome (MetS) at an earlier stage in Korean population. Metabolic parameters such as body composition, blood pressure (BP), fasting glucose, total cholesterol, triglyceride (TG), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), thyroid-stimulating hormone (TSH) and free thyroxine 4 (fT4) were measured. During a mean follow-up of 3 yr, 5,998 Koreans ages over 18 yr were assessed. There were 694 cases of MetS at follow-up. The mean age of the subjects was 45.6 +/- 9.5 yr. Mean level of TSH was 2.02 +/- 1.50 mIU/L, mean level of fT4 was 1.23 +/- 0.20 rhoM/L. At baseline, TSH levels and fT4 levels were associated to waist circumference, BP, glucose and lipids in the subjects. Increase in systolic blood pressure, diastolic blood pressure (DBP), total cholesterol and TG were significantly associated with changes in TSH levels after adjustment. Changes in DBP, TG, HDL-C and fasting glucose were significantly associated with changes in fT4 levels after adjustment. Increase in TSH levels even after further controlling for baseline TSH level predicted the MetS over the study period. In conclusion, there is a relationship between thyroid function and cardiovascular risk factors, such as BP, total cholesterol, TG, HDL-C and fasting glucose. Also, higher levels of TSH may predict the MetS in Korean.
