A case of trousseaus syndrome associated with adenocarcinoma of the lung.
- Author:
Young Jae CHO
1
;
Hee Joung KIM
;
Ji Eun LEE
;
Joon Sung JOH
;
Sung Koo HAN
;
Young Soo SHIM
;
Chul Gyu YOO
Author Information
1. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine, Seoul, Korea. cgyoo@snu.ac.kr
- Publication Type:Case Report
- Keywords:
Adenocarcinoma;
Lung;
Trousseau's syndrome
- MeSH:
Adenocarcinoma*;
Amputation;
Arteries;
Coronary Vessels;
Female;
Humans;
Knee;
Lung*;
Myocardial Infarction;
Thromboembolism;
Thrombophilia;
Thromboplastin
- From:Korean Journal of Medicine
2007;72(6):673-678
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In 1865, Armand Trousseau recognized the first relationship between a neoplastic disease and a thromboembolic disorder. Since then, many cases have been reported and have been termed as Trousseau's syndrome. One mechanism of hypercoagulability was considered to be the activation of coagulation systems by a tissue factor secreted by neoplastic cells, but accurate pathophysiology still remains unknown. We report a case of a multiple and recurrent thromboembolism in a patient with adenocarcinoma of the lung. A woman aged 68 years with an acute thromboembolism at her right distal calf artery was diagnosed as having adenocarcinoma of the lung. She underwent a thromboembolectomy two times, but had to receive surgery for a below knee amputation. Multiple and recurrent thromboembolic events then attacked her cerebral and coronary arteries, which led to cerebral and myocardial infarctions. She expired by a progression of the adenocarcinoma of the lung after about six months.
