The Efficacy of Preemptive Analgesia With Pregabalin in Septoplasty.
- Author:
Joon Ho KIM
1
;
Min Young SEO
;
Sang Duk HONG
;
Jungbok LEE
;
Seung Kyu CHUNG
;
Hyo Yeol KIM
;
Hun Jong DHONG
Author Information
1. Department of Rhinology, HANA ENT HOSPITAL, Seoul, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Postoperative pain;
Pregabalin;
Septoplasty;
Preemptive analgesia
- MeSH:
Analgesia*;
Analgesics;
Humans;
Incidence;
Nausea;
Neuralgia;
Pain, Postoperative;
Vomiting;
Pregabalin
- From:Clinical and Experimental Otorhinolaryngology
2014;7(2):102-105
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES: Pregabalin is used to treat neuropathic pain and has shown analgesic properties in postoperative pain. The aim of this study was to investigate the effectiveness and safety of pregabalin in reducing postoperative pain in patients after septoplasty. METHODS: Forty-seven patients scheduled for elective septoplasty were randomly assigned to groups that received either pregabalin (150 mg) or placebo, both one hour before surgery and 12 hours after the initial dose. Pain (verbal numerical rating scale, VNRS) and side effect assessments were performed at 6, 12, 12 to 24, and 24 to 48 hours postoperatively. RESULTS: From 1 to 12 hours postoperatively, VNRS scores for pain were lower in the pregabalin group (n=24) than in the placebo group (n=23; P<0.05). The number of patients who needed rescue analgesics was lower in the pregabalin group (P=0.042). The incidence of nausea and vomiting did not differ between groups (P=0.666), and the incidence of sedation was higher in the placebo groups (P=0.022). CONCLUSION: The perioperative administration of oral pregabalin (150 mg twice) is an effective and safe way to reduce early postoperative pain in patients undergoing septoplasty.
