Evaluation of the Abbott Cell-Dyn Sapphire Hematology Analyzer.
10.3343/kjlm.2007.27.3.162
- Author:
Younhee PARK
1
;
Jaewoo SONG
;
Sungwook SONG
;
Kyung Soon SONG
;
Mee Suk AHN
;
Mi Sook YANG
;
Il KIM
;
Jong Rak CHOI
Author Information
1. Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea. cjr0606@yumc.yonsei.ac.kr
- Publication Type:Original Article ; English Abstract ; Evaluation Studies
- Keywords:
Cell-Dyn Sapphire;
Performance;
Correlation
- MeSH:
Analysis of Variance;
Autoanalysis;
Blood Cell Count/*instrumentation/methods;
Blood Specimen Collection;
Diagnostic Errors;
Humans;
Reproducibility of Results;
Sensitivity and Specificity
- From:The Korean Journal of Laboratory Medicine
2007;27(3):162-168
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The performance of Cell-Dyn Sapphire (Abbott Diagnostic, USA) was compared to the Bayer Advia 2120 (Bayer Diagnostics, USA), Sysmex XE-2100 (Sysmex Corporation, Japan), and reference microscopy. METHODS: Three hundred samples for routine CBC and WBC differentials were randomly chosen for a comparison analysis. The Cell-Dyn Sapphire system was evaluated according to the linearity, imprecision, inter-instrument correlations, and white blood cell differential. RESULTS: The CBC parameters (WBC, RBC, hemoglobin and platelet) showed a significant linearity with correlation coefficients greater than 0.99 (P<0.0001). Coefficients of variation (CV) for withinrun and differential count of WBC were less than 5% except for Total CV for monocytes, eosinophils, and basophils and within-run CV for low valued eosinophils. The correlation coefficients with manual count were lower in monocytes, eosinophils, and basophils than in neutrophils and lymphocytes. The correlation with other hematology anlayzers was significant exclusive of basophils. CONCLUSIONS: These results demonstrate that the Cell-Dyn Sapphire has a good linearity, an acceptable reproducibility, a minimal carryover, and a comparable performance with the sysmex XE-2100 and Advia 2120.
