The Re-infection of Helicobacter pylori and the Presence of Metachronous Lesions after Endoscopic Mucosal Resection of Gastric Neoplasias.
- Author:
Min HUH
1
;
Byung Wook KIM
;
Bo In LEE
;
Hwang CHOI
;
Se Hyun CHO
;
Jeong Seon JI
;
Kyu Yong CHOI
;
Min Kuk KIM
;
Hyun Jung JUNG
;
Jeong Won JANG
;
Hiun Suk CHAE
;
In Sik CHUNG
Author Information
1. Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. bleok@dreamwiz.com
- Publication Type:Original Article
- Keywords:
Endoscopic mucosal resection;
H. pylori;
Metachronous lesions
- MeSH:
Adenocarcinoma;
Adenoma;
Biopsy;
Follow-Up Studies;
Helicobacter;
Helicobacter pylori;
Humans;
Peptic Ulcer
- From:Korean Journal of Gastrointestinal Endoscopy
2008;36(5):257-261
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The aims of this study were to determine the H. pylori re-infection rate in patients that underwent endoscopic mucosal resection (EMR) due to a gastric adenoma and gastric adenocarcinoma, and to define the correlation between H. pylori re-infection and the presence of metachronous lesions. METHODS: An endoscopic examination with a biopsy was performed at six months, 12 months, and every year thereafter to determine if H. pylori re-infection occurred and if metachronous lesions were present in patients that had undergone EMR (EMR group). At least a three-year follow-up examination was performed, and patients with an on-site recurrent lesion were excluded. The re-infection rate was compared to the rate in patients with peptic ulcers (control group). RESULTS: Six patients (24%) among the 25 patients included in this study had H. pylori re-infection, an indication of a high re-infection rate as compared to the rate in patients with peptic ulcers (p=0.03). Two patients (33.3%) who were re-infected with H. pylori had metachronous lesions (p=0.009). CONCLUSIONS: Determination of the H. pylori status during a follow-up study after EMR is essential and re-eradication therapy is recommended in patients with H. pylori re-infection to prevent metachronous lesions.
