Effectiveness of 10 Day-sequential Therapy for Helicobacter pylori Eradication in Korea.
- Author:
Woo Hyuk CHOI
1
;
Dong Il PARK
;
Suk Joong OH
;
Yoo Hum BAEK
;
Cheul Ho HONG
;
Eun Jung HONG
;
Min Jun SONG
;
Sung Keun PARK
;
Jung Ho PARK
;
Hong Joo KIM
;
Yong Kyun CHO
;
Chong Il SOHN
;
Woo Kyu JEON
;
Byung Ik KIM
Author Information
1. Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. diksmc.park@samsung.com
- Publication Type:Original Article ; Comparative Study ; English Abstract ; Randomized Controlled Trial
- Keywords:
Helicobacter pylori;
Sequential therapy;
Eradication rate
- MeSH:
Adult;
Amoxicillin/administration & dosage;
Anti-Bacterial Agents/*administration & dosage;
Anti-Ulcer Agents/administration & dosage;
Data Interpretation, Statistical;
Drug Therapy, Combination;
Female;
Helicobacter Infections/*drug therapy/microbiology;
*Helicobacter pylori;
Humans;
Korea;
Male;
Metronidazole/administration & dosage;
Middle Aged;
Omeprazole/administration & dosage;
Time Factors;
Treatment Outcome
- From:The Korean Journal of Gastroenterology
2008;51(5):280-284
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Antibiotic resistance and poor compliance are the main causes of Helicobacter pylori (H. pylori) eradication failure. Proton pump inhibitor (PPI)-based triple therapy is the most preferred regimen in clinical practice. However, a critical fall in the H. pylori eradication rate has been observed in the recent years. A novel 10 day-sequential therapy consists of five days of dual therapy followed by five days of triple therapy regimen has recently been described. We aimed to evaluate whether 10 day-sequential therapy eradicated H. pylori infection better than the PPI-based triple therapy in Korea. METHODS: 158 patients with proven H. pylori infection were randomized to receive either 10 day-sequential therapy (20 mg of omeprazole, 1.0 g of amoxicillin, each administered twice daily for the first 5 days, followed by 20 mg of omeprazole, 500 mg of clarithromycin, 500 mg of metronidazole, each administered twice daily for the remaining 5 days) or PPI-based triple therapy (20 mg of omeprazole, 1.0 g of amoxicillin, 500 mg of clarithromycin, each administered twice daily for 1 week). Outcome of eradication therapy was assessed 8 weeks after the cessation of treatment. RESULTS: Eradication rates of 10 day-sequential therapy and PPI-based triple therapy were 77.9% (60/77) and 71.6% (58/81) by intention to treat analysis, respectively (p=0.361). By per protocol analysis, eradication rates of 10 day-sequential therapy and triple therapy were 85.7% (60/70) and 76.6% (58/76), respectively (p=0.150). There were no significant differences in adverse event rates and treatment compliance between two groups. CONCLUSIONS: The 10 day-sequential therapy regimen failed to achieve significantly higher eradication rates than PPI-based triple therapy.
