Median Effective Concentration (EC(50)) of Propofol for Insertion of Laryngeal Mask Airway and Laryngeal Tube in Children.
10.4097/kjae.2006.51.3.330
- Author:
Hye Jin PARK
1
;
Tae Gyoon YOON
;
Chong Sung KIM
;
Seong Deok KIM
;
Hee Soo KIM
Author Information
1. Department of Anesthesiology, College of Medicine, Eulji University, Seoul, Korea. dami0605@snu.ac.kr
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
anesthesia intravenous;
child;
laryngeal mask airway;
propofol
- MeSH:
Anesthesia;
Anesthesia, General;
Child*;
Humans;
Laryngeal Masks*;
Orthopedics;
Plasma;
Propofol*;
Surgery, Plastic
- From:Korean Journal of Anesthesiology
2006;51(3):330-334
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The median effective concentration, EC(50), for the supraglottic airway (predicted plasma concentration equilibrated with the effect site at which supraglottic airway insertion is successful in 50% of patients) of propofol in children was not known. The aim of this study was to determine the EC(50) with a target-controlled infusion of propofol to insert a classic laryngeal mask airway (LMA) and laryngeal tube (LT) in pediatric patients. METHODS: Pediatric patients scheduled for urologic, orthopedic, or plastic surgery lasting less than 2 hr under general anesthesia were enrolled in this study. The patients were divided into two groups in a randomized, double blind manner. After applying a standard cardiorespiratory monitor, anesthesia was carried out with a target-controlled infusion (TCI) using the stelpump program. The initial target concentration of propofol was 5microgram/ml, and in accordance with Dixon's up-and-down, the propofol concentration for consecutive patients in each group was varied with increments or decrements of 0.2microgram/ml based on the previous patient insertion result. RESULTS: The EC(50) of propofol required to insert a LMA and LT was 5.5+/-0.2microgram/ml and 5.6+/-0.2microgram/ml, respectively. CONCLUSIONS: The EC50 of propofol is similar for LMA and LT.
