Microsatellite Instability in Colorectal Carcinomas.
- Author:
Hee Jeong CHA
1
;
Dong Kyun WOO
;
Sun Hee KIM
;
Yong ll KIM
;
Jae Gahb PARK
;
Woo Ho KIM
Author Information
1. Department of Pathology, Cancer Research Institute and Department of Surgery, Seoul National University College of Medicine, Seoul 110-799, Korea. woohokim@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Colorectal neoplasms;
Microsatellite repeats;
Sequence analysis
- MeSH:
Adenocarcinoma;
Adenocarcinoma, Mucinous;
Colon;
Colonic Neoplasms;
Colorectal Neoplasms*;
DNA Mismatch Repair;
Humans;
Incidence;
Microsatellite Instability*;
Microsatellite Repeats*;
Sequence Analysis
- From:Korean Journal of Pathology
2001;35(2):111-114
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Microsatellite instability (MSI), which is caused by a deficient mismatch repair system, is seen in most of the hereditary non-polyposis colon cancers and a portion of sporadic colorectal cancers. METHODS: Two hundreds forty-six consecutive sporadic colorectal cancer patients were analyzed for MSI using an ABI 377 automatic sequencer and fluorescent dye-labelled primers (BAT-25 and BAT-26). RESULTS: The overall incidence of MSI in studied cases was 9.8% (24/246). This incidence is lower than most of the reported incidences in western countries. The incidence of MSI tumors in the proximal colon was 29.6%, while that of the distal colon was only 4.2% (p<0.001). MSI in sporadic colorectal cancers was more prevalent in poorly differentiated adenocarcinoma. In contrast to western countries, mucinous carcinoma did not show higher incidence of MSI. CONCLUSION: The results suggest that MSI frequently occurs in cancers of the proximal colon and in tumors with poorly differentiated histology.
