The Expression of Transforming Growth Factor-1 and Its Signaling Receptors in Human Colorectal Carcinoma.
- Author:
Gyeong Seon KIM
1
;
Joo Heon KIM
;
Woo Sung MOON
;
Myoung Ja CHUNG
;
Dong Geun LEE
;
Myoung Jae KANG
Author Information
1. Department of Pathology, College of Medicine, Institute for Medical Science, Chonbuk National University, Chonju 561-712, Korea. mjkang@moak.chonbuk.ac.kr
- Publication Type:Original Article
- Keywords:
Colorectal neoplasms;
Transforming growth factor beta;
Receptors;
Immunohistochemistry
- MeSH:
Adenoma;
Carcinogenesis;
Colon;
Colorectal Neoplasms*;
Humans*;
Immunohistochemistry;
Mucous Membrane;
Rectum;
Signal Transduction;
Transforming Growth Factor beta
- From:Korean Journal of Pathology
2001;35(2):115-122
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Resistance to the potent growth inhibitory effects of TGF- (transforming growth factor-) is a characteristic of many malignancies. TGF- insensitivity has been attributed to alterations in the number and function of the TGF- receptors as well as disturbances of downstream signal transduction. The aim of this study was to examine the expression of TGF-1 and its receptors in human colorectal cancer tissue and determine its relationship with cancer growth and with prognostic factors. METHODS: Immunohistochemical staining of TGF-1, TGF-RI, and TGF-RII was performed on 20 human colorectal adenomas, 30 carcinomas and 10 normal mucosas as a control. RESULTS: The staining indices of TGF-1, TGF-RI, and TGF-RII increased in adenomas and carcinomas compared with normal mucosas and adenomas, respectively. In adenomas the staining index of TGF-1 significantly increased with the severity of atypism. The staining index of TGF-RII increased in the carcinomas in the right colon and rectum, compared with those in the left colon. CONCLUSION: The enhanced expression of TGF-1, TGF-RI and II in the colorectal carcinoma suggests an important role of colorectal carcinogenesis and tumor progression.
