Impact of Caveolin-1 Expression on the Prognosis of Transitional Cell Carcinoma of the Upper Urinary Tract.
10.3346/jkms.2008.23.2.296
- Author:
Dae Sung CHO
1
;
Hyunee YIM
;
Kang Su CHO
;
Sung Joon HONG
;
Nam Hoon CHO
;
Sun Il KIM
;
Hyun Soo AHN
;
Se Joong KIM
Author Information
1. Department of Urology, Ajou University School of Medicine, Suwon, Korea. sejoong@ajou.ac.kr
- Publication Type:Original Article
- Keywords:
Caveolin 1;
Prognosis;
Carcinoma, Transitional Cell;
Upper Urinary Tract
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Carcinoma, Transitional Cell/*diagnosis/*metabolism;
Caveolin 1/*biosynthesis;
Disease Progression;
Disease-Free Survival;
Female;
Gene Expression Profiling;
*Gene Expression Regulation, Neoplastic;
Humans;
Male;
Middle Aged;
Prognosis;
Urologic Neoplasms/*diagnosis/*metabolism
- From:Journal of Korean Medical Science
2008;23(2):296-301
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study aimed to investigate the relationship of caveolin-1 expression with prognosis in patients with transitional cell carcinoma of the upper urinary tract (TCCUUT). Formalin-fixed, paraffin-embedded tissue sections of TCC-UUT from 98 patients, who had undergone radical nephroureterectomy, were stained immunohistochemically using antibodies against caveolin-1. The expression pattern of caveolin- 1 was compared with the clinicopathological variables. The caveolin-1 expression was significantly correlated with T stage (p<0.001) and grade (p=0.036). The survival rate of patients with caveolin-1 positive tumors was significantly lower than that of patients with caveolin-1 negative tumors (p<0.0001). The univariate analyses identified T stage, grade, and caveolin-1 expression as significant prognostic factors for cancer-specific survival, whereas the multivariate analyses indicated that T stage and caveolin-1 expression were independent prognostic factors. These results show that the increased expression of caveolin-1 is associated with tumor progression and poor prognosis in TCC-UUT, suggesting that caveolin-1 may play an important role in the progression of TCC-UUT.
