Effect of Cyclophospharmide Pulse and Combined with Per Oral Low Dose Glucorticoid on Pulmonary Fibrosis in Patient with Sistemic Sclerosis.
- Author:
Gwan Gyu SONG
1
;
Young Ho LEE
;
Jae Jeong SHIM
;
Kyung Ho KANG
Author Information
1. Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Scleroderma;
Pulmonary fibrosis;
Cyclophosphamide;
Treatment
- MeSH:
Cough;
Cyclophosphamide;
Dyspnea;
Follow-Up Studies;
Herpes Zoster;
Humans;
Infusions, Intravenous;
Lung Diseases;
Lung Diseases, Interstitial;
Prednisolone;
Pulmonary Fibrosis*;
Scleroderma, Systemic;
Sclerosis*
- From:The Journal of the Korean Rheumatism Association
1996;3(2):187-194
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To investigate the efficacy of combined intravenous cyclophophamide pulse and low dose oral prednisolone treatment in patients with systemic sclerosis with -interstitial lung disease. METHOD: Six patients with systemic sclerosis with interstitial lung disease were treated with intravenous infusion of cyclophosphamide(0. 75g/m2 body surface area) and low dose oral prednisolone (10mg/day). RESULTS: 1) Respiratory symptoms, cough and dyspnea, were improved in all patients in both frequency and severity. 2) The mean value of FVC, FEV1, and DLC test showed tendency of increase during the follow up period (upto 24 months) compared to decrease in the past studies. 3)There was no serious side effect during the trreatment. Herpes zoster was developede in I patient during treament. CONCLUSIONS: Combined intravenous cyclophosphamide pulse and low dose oral prednisolone treatment is effective for the patients with systemic sclerosis with interstitial lung disease. A controlled prospective trial is warranted in patients with systemic sclerosis with interstitial lung disease.
