A Case of Hyper-IgE Syndrome Presenting as a Vesiculopustular Eruption in an Infant.
- Author:
Jae Hoon CHO
1
;
Mi Yeon KIM
;
Young Min PARK
;
Hyung Ok KIM
Author Information
1. Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea. knderma@cmc.cuk.ac.kr
- Publication Type:Case Report
- Keywords:
Hyper-IgE syndrome;
Vesiculopustular eruption;
Infancy
- MeSH:
Infant;
Male;
Female;
Humans;
Biopsy
- From:Korean Journal of Dermatology
2004;42(1):108-110
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The hyper-IgE syndrome is characterized by marked elevated levels of IgE, recurrent cutaneous and systemic staphylococcal infections, peripheral eosinophilia and defective neutrophil chemotaxis. The characteristic cutaneous findings of hyper-IgE syndrome have been reported as an eczematous or atopic dermatitis-like eruption with multiple skin abscesses, whereas the initial presentation of hyper-IgE syndrome in infancy as a papulopustular or vesicular eruption. We report a case of hyper-IgE syndrome featuring a vesiculopustular eruption in infancy. A 15-month-old baby presented with recurrent vesiculopustules on the face and hands. The biopsy specimen revealed eosinophilic spongiotic dermatitis with an eosinophil-predominant perivascular lymphocytic infiltration. These findings might lead to an earlier recognition of hyper-IgE syndrome and an institution of appropriate treatment.
