Histopathological Changes of the Extraocular Muscles After the Retrobulbar Anesthesia.
- Author:
Bong Leen CHANG
1
;
Geon U LEE
Author Information
1. Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.
- Publication Type:Original Article
- MeSH:
Anesthesia*;
Anesthetics;
Anesthetics, Local;
Animals;
Bupivacaine;
Diplopia;
Epinephrine;
Harderian Gland;
Humans;
Lidocaine;
Muscles*;
Optic Nerve;
Rabbits
- From:Journal of the Korean Ophthalmological Society
1987;28(5):1053-1061
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Local anesthetics that are commonly used in ophthalmic surgery(0.5% bupivacaine hydrochloride, 2.0% lidocaine hydrohloride, 0.38% bupivacaine-1.0% lidocaine-1:100,000 epinephrine mixture) were injected into the retrobulbar space of rabbit eyes. Physiologic saline was injected into that spaces in control group in the same manner. All three anesthetics produced degeneration of the extraocular muscles to a varying extent. Muscle degeneration was followed by rgeneration of the damaged muscle fibers. In addition to muscle damage, severe damage to harderian gland was also seen in lidocaine-injected group. The optic nerve was not affected. With these findings in rabbits, it is hypothesized that the temporary diplopia and ptosis sometimes seen in patients after ophthalmic surgery might be due to anestheticsinduced damage to the extraocular muscles.
