Effects of pretreatment with intravenous palonosetron for propofol-remifentanil-based anesthesia in breast and thyroid cancer surgery: a double-blind, randomized, controlled study.
10.4097/kjae.2014.67.1.13
- Author:
Kye Hyeok LEE
1
;
Sung Kyu RIM
;
Ji Yeon LEE
;
So Young LEE
;
Su Nam LEE
;
Eun Ju LEE
;
Ji Heui LEE
Author Information
1. Department of Anesthesiology and Pain Medicine, Korean Cancer Center Hospital, Seoul, Korea. jiheui0255@naver.com
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Pain;
Palonosetron;
Postoperative nausea and vomiting;
Propofol
- MeSH:
Anesthesia*;
Anesthesia, Intravenous;
Breast*;
Humans;
Incidence;
Pain, Postoperative;
Postoperative Nausea and Vomiting;
Propofol;
Shivering;
Thyroid Neoplasms*
- From:Korean Journal of Anesthesiology
2014;67(1):13-19
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: We postulated that palonosetron, a novel antiemetic agent, might have the effect of alleviating injection pain from propofol and rocuronium. A double-blind, controlled study was undertaken to evaluate the effect of palonosetron on injection pain during total intravenous anesthesia and postoperative nausea and vomiting (PONV) using propofol-remifentanil in breast and thyroid cancer surgery. METHODS: Sixty patients were randomly allocated to one of two groups. Before injection of propofol and rocuronium, patients in group S (n = 30) received 4 ml of saline and patients in group P (n = 30) received 75 microg (1.5 ml) of palonosetron mixed with 2.5 ml of saline (n = 30). Patients were evaluated by a blinded anesthesiologist with regard to the scoring of injection pain of propofol, withdrawal response by rocuronium, PONV, shivering, postoperative pain, recall of pain, and overall satisfaction. RESULTS: The differences between groups in the incidence of injection pain due to propofol and rocuronium were insignificant. However, in group P, the severity of propofol-induced injection pain (3% vs. 33%, P = 0.003) and postoperative pain (P = 0.038) was significantly lower during the first 12 h after surgery. No differences were observed between the groups with respect to PONV, shivering, recall of pain, and overall satisfaction. CONCLUSIONS: We concluded that pretreatment of palonosetron was effective to reduce the severity of propofol-induced injection pain and early postoperative pain, although it did not reduce the incidence of injection pain from propofol and rocuronium.
