NEUROLEPTIC MALIGNANT SYNDROME-LIKE STATE DUE TO DEPOT OF CHLORPROMAZINE: A Case Report.
- Author:
Young Ho JIN
1
;
Jae Baek LEE
Author Information
1. Department of Emergency Medicine, Chonbuk National University Medicine School, Korea.
- Publication Type:Case Report
- Keywords:
Hyperthermia;
Chlorpromazine;
Neuroleptic malignant syndrome
- MeSH:
Chlorpromazine*;
Diazepam;
Diuretics;
Emergencies;
Fever;
Muscle Rigidity;
Neuroleptic Malignant Syndrome;
Neurotransmitter Agents
- From:Journal of the Korean Society of Emergency Medicine
1997;8(1):98-102
- CountryRepublic of Korea
- Language:English
-
Abstract:
The neuroleptic malignant syndrome(NMS) results primarily from an imbalance of central neurotransmitters and typically occurs after acute or chronic neuroleptic drug use rather than after neuroleptic overdosage. It is a rare and serious iatrogenic syndrome that is characterized by hyperthermia, muscle rigidity, autonomic dysfunctions and altered mental status. We have observed a case of NMS-like state due to depot of chlorpromazine(CPZ) and have experienced symptomatic and supportive treatment, which including body surface cooling, fluid administration, diuretics, and diazepam. So, in order to provide interests with this clinical situation for emergency physician, pathophysiology is discussed with references to the possibility of NMS in our case and symptomatology and managements are also reviewed.
