Simulation of Proliferative Vitreoretinopathy in Pigmented Rabbits.
- Author:
Jae Sun LEE
1
;
Jaeheung LEE
Author Information
1. Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.
- Publication Type:Original Article
- MeSH:
Choroid;
Collagen;
Fibroblasts;
Incidence;
Membranes;
Neuroglia;
Ophthalmoscopes;
Rabbits*;
Retinal Detachment;
Retinal Perforations;
Retinaldehyde;
Vitreoretinopathy, Proliferative*
- From:Journal of the Korean Ophthalmological Society
1987;28(6):1229-1238
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Proliferative vitreoretinopathy(PVR) is the most common cause of failure in retinal reattachment surgery. We performed three different procedures in 20 pigmented rabbits to get a simple model to induce experimental PVR. Rabbits were assigned randomly to three groups(I, II and III). Group I rabbits(5 rabbits, 10 eyes) received normal saline into vitreous cavity, after iatrogenic retinal tear was made. In group n rabbits(8 rabbits, 8 eyes), suspension of retinal pigment epithelium(RPE) and choroid of left eye was transferred into vitreous cavity of right eye. In group III rabbits(7 rabbits, 7 eyes), suspension of RPE and choroid of left eye was transferred into vitreous cavity of right eye after iatrogenic retinal tear was made. We observed the fundus for 2 months with, indirect ophthalmoscope. Incidence of retinal detachment of group I was zero(0/10) , that of group II was 37.5%(3/8), and that of group III was 85.7%(6/7). Electron microscopic findings of vitreous strand of one eye of group n showed central melanocytic core, peripheral fibroblast, and intercellular collagen fibril. Electron microscopic finding of one eye of group III revealed subretinal membrane composed of suspected RPE and glial cell.
