15-Hydroxyprostaglandin Dehydrogenase in Colorectal Mucosa as a Potential Biomarker for Predicting Colorectal Neoplasms.
10.3346/jkms.2013.28.8.1154
- Author:
Hyo Jeong LEE
1
;
Dong Hoon YANG
;
Yeon Mi RYU
;
Miyeoun SONG
;
Ho June SONG
;
Kee Wook JUNG
;
Kyung Jo KIM
;
Byong Duk YE
;
Jeong Sik BYEON
;
Eun Kyung CHOI
;
Suk Kyun YANG
;
Jin Ho KIM
;
Seung Jae MYUNG
Author Information
1. Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sjmyung@amc.seoul.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
15-Hydroxyprostaglandin Dehydrogenase;
Biological Markers;
Colorectal Neoplasms
- MeSH:
Aged;
Colorectal Neoplasms/*diagnosis/enzymology/pathology;
Down-Regulation;
Female;
Humans;
Hydroxyprostaglandin Dehydrogenases/genetics/*metabolism;
Intestinal Mucosa/*enzymology;
Male;
Middle Aged;
Neoplasm Staging;
Neoplasms, Multiple Primary/enzymology/pathology;
Neoplasms, Second Primary/enzymology/pathology;
Odds Ratio;
Predictive Value of Tests;
RNA, Messenger/metabolism;
Real-Time Polymerase Chain Reaction;
Risk Factors;
Tumor Markers, Biological/*metabolism
- From:Journal of Korean Medical Science
2013;28(8):1154-1160
- CountryRepublic of Korea
- Language:English
-
Abstract:
15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is downregulated during the early stages of colorectal carcinogenesis. The aim of the present study was to investigate the potential role of 15-PGDH in normal-appearing colorectal mucosa as a biomarker for predicting colorectal neoplasms. We obtained paired tumor and normal tissues from the surgical specimens of 32 sporadic colorectal cancer patients. mRNA expression of 15-PGDH was measured using a quantitative real-time PCR assay. We evaluated the association between 15-PGDH mRNA expression in normal-appearing mucosa, the presence of synchronous adenoma, and the cumulative incidence of metachronous adenoma. The relative 15-PGDH expression of normal-appearing mucosa in patients with synchronous adenoma was significantly lower than in patients without synchronous adenoma (0.71 vs 1.00, P = 0.044). The patients in the lowest tertile of 15-PGDH expression in normal-appearing mucosa were most likely to have synchronous adenoma (OR: 10.5, P = 0.024). Patients with low 15-PGDH expression in normal-appearing mucosa also demonstrated more advanced stage colorectal cancer (P = 0.045). However, there was no significant difference in the cumulative incidence of metachronous adenoma according to 15-PGDH mRNA expression in normal-appearing mucosa (P = 0.333). Hence, 15-PGDH in normal-appearing colorectal mucosa can be a useful biomarker of field effect for the prediction of sporadic synchronous neoplasms.
