Incidence, Etiology, and Outcomes of Rhabdomyolysis in a Single Tertiary Referral Center.
10.3346/jkms.2013.28.8.1194
- Author:
Jae Seok PARK
1
;
Min Sook SEO
;
Hyo Wook GIL
;
Jong Oh YANG
;
Eun Young LEE
;
Sae Yong HONG
Author Information
1. Department of Internal Medicine, Soonchunhyang University, College of Medicine, Cheonan, Korea. syhong@sch.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Acute Kidney Injury;
Intoxication;
Pesticides;
Rhabdomyolysis;
Surfactant
- MeSH:
Adult;
Age Factors;
Aged;
Alcohol Drinking;
Female;
Hospitalization;
Humans;
Incidence;
Length of Stay;
Male;
Middle Aged;
Pesticides/poisoning;
Rhabdomyolysis/*epidemiology/etiology;
Sex Factors;
Tertiary Care Centers;
Treatment Outcome
- From:Journal of Korean Medical Science
2013;28(8):1194-1199
- CountryRepublic of Korea
- Language:English
-
Abstract:
We have encountered numerous cases of rhabdomyolysis associated with acute pesticide intoxication; however, the cause, incidence, and treatment outcomes of rhabdomyolysis have not been studied. The current study involved 2,125 patients hospitalized with acute chemical poisoning. Based on clinical and laboratory parameters and treatment outcomes, we found that overall incidence of rhabdomyolysis in our hospital was 0.06% (93 of 143,830 patients admitted), but the incidence associated with acute pesticide intoxication was 1.8% (33 of 1,793 cases). The incidence of rhabdomyolysis after pesticide intoxication was significantly higher in men than in women (P = 0.010). The amount of pesticide ingested was significantly higher in rhabdomyolysis patients than that in those who did not develop rhabdomyolysis (mean +/- SD, 114.1 +/- 79.5 mL vs 74.1 +/- 94.2 mL, P = 0.010). Our results show that pesticide intoxication is a frequent cause of rhabdomyolysis and is more common among men than women. The volume of pesticide ingested, and not the degree of human toxicity, is the main factor influencing the incidence of rhabdomyolysis.
