The Presence of Anti-ribonucleoprotein at Diagnosis Is Associated with the Flare during the First Follow-up Year in Korean Patients with Systemic Lupus Erythematosus.
10.4078/jrd.2016.23.3.154
- Author:
Dae Sik KIM
1
;
Jung Yoon PYO
;
Se Jin BYUN
;
Sung Soo AHN
;
Jungsik SONG
;
Yong Beom PARK
;
Soo Kon LEE
;
Sang Won LEE
Author Information
1. Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. laza00@yuhs.ac
- Publication Type:Original Article
- Keywords:
Anti-ribonucleoprotein;
Flare;
Systemic lupus erythematosus;
Systemic lupus erythematosus disease activity index
- MeSH:
Antibodies;
Arthritis;
Autoimmune Diseases;
Diagnosis*;
Exanthema;
Follow-Up Studies*;
Humans;
Incidence;
Lupus Erythematosus, Systemic*;
Medical Records;
Retrospective Studies;
Ulcer
- From:Journal of Rheumatic Diseases
2016;23(3):154-160
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: The aim of this study was to examine whether the presence of anti-ribonucleoprotein (anti-RNP) antibodies at diagnosis is associated with systemic lupus erythematosus (SLE) flares in newly diagnosed patients during the first year of follow-up. METHODS: The medical records of 71 newly diagnosed SLE patients without other concomitant autoimmune disease, serious infection, or malignancy were reviewed retrospectively. SLE flares were defined according to the SLE Disease Activity Index 2000. Patients were divided into 2 groups according to the presence or absence of anti-RNP, and variables were compared between the groups. RESULTS: During the first year of follow-up, SLE patients with anti-RNP at diagnosis more frequently presented with mucosal ulcers (p=0.003), rash (p=0.001), and arthritis (p=0.007), compared to those without anti-RNP. The SLE flare incidence was remarkably higher in patients with anti-RNP than in those without anti-RNP (62.5% vs. 23.1%, p=0.001). SLE patients with anti-RNP at diagnosis had a significantly higher risk of ever experiencing a SLE flare during the first year of follow-up, compared to those without anti-RNP (odds ratio=8.250). CONCLUSION: In conclusion, SLE patients with anti-RNP at diagnosis were more than 8-fold more likely to experience an SLE flare during the first year of follow-up.
