Eleven Years' Experience with Unexpected Antibody Screening Tests Including a Di(a) Cell in Transfusion Candidates.
- Author:
Soon Jung OK
1
;
Shine Young KIM
;
In Suk KIM
;
Eun Yup LEE
;
Hyung Hoi KIM
Author Information
1. Department of Laboratory Medicine, School of Medicine, Pusan National University, Busan, Korea. hhkim@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
Unexpected antibody;
Antibody screening test;
Anti Di(a) antibody
- MeSH:
Antibodies;
Asian Continental Ancestry Group;
Humans;
Incidence;
Korea;
Mass Screening
- From:Korean Journal of Blood Transfusion
2013;24(1):64-70
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The Di(a) antigen has been detected with a relatively higher incidence among the Korean and Southeast Asian population. A 'Type and Screen' procedure is recommended for efficient transfusion, therefore, we perform antibody screening tests using antibody screening panels containing a Di(a) cell. The purpose of this study was to report on the experience of unexpected antibody screening test including a Di(a) cell in the Korean population. METHODS: We analyzed the results of antibody screening testing and identification performed during the recent 11-year period from January 2002 to December 2012. A commercially available three-cell antigen panel (Diacell I, II, Di(a); DiaMed, Murten, Switzerland) was used for antibody screening. Antibodies were identified using a LISS/Coombs gel card and NaCl/Enzyme card, using the DiaMed-ID system (DiaMed, Murten, Switzerland). RESULTS: The frequency of unexpected antibodies was 1.23% (1,918/156,161); the most frequently detected antibodies were anti-E (292 samples), followed by anti-E,c (127 samples), anti-Le(a) (103 samples), and anti-Di(a) (91 samples). CONCLUSION: Results of this study showed that the most identified unexpected antibodies were clinically significant, and, in particular, anti-Di(a) antibodies are detected frequently in the Korean population. Thus, unexpected antibody screening test including a Di(a) cell is thought to be helpful in Korea for safe transfusion.
