Development of Animal Models of Otitis Media.
- Author:
Moo Kyun PARK
1
;
Byung Don LEE
Author Information
- Publication Type:In Vitro ; Review
- Keywords: Otitis media; Cholesteatoma; In vitro; Animal model
- MeSH: Animals; Cholesteatoma; Ear Ossicles; Ear, Middle; Eustachian Tube; Humans; Inflammation; Models, Animal; Otitis; Otitis Media; Otitis Media with Effusion
- From:Korean Journal of Audiology 2013;17(1):9-12
- CountryRepublic of Korea
- Language:English
- Abstract: Otitis media is defined as inflammation of the middle ear, including the auditory ossicles and the Eustachian tube. Otitis media is a major health problem in many societies. The causes of otitis media includes infection and anatomic/physiologic, host, and environmental factors. In general, otitis media is a childhood disease, and anatomic and physiologic changes have great effects on its development. Thus, in vitro or human experimental studies of otitis media are difficult. Several experimental animal models have been introduced to investigate the pathogenesis and treatment of otitis media. However, none are ideal. The aim of this review is to provide a brief overview of the current status of animal models of otitis media with effusion, acute otitis media, and cholesteatoma. This review will assist determination of the most appropriate animal models of otitis media.
