Neuropsychological and Behavioral Profiles in Attention-Deficit Hyperactivity Disorder Children of Parents with a History of Mood Disorders: A Pilot Study.
- Author:
Subin PARK
1
;
Kang E M HONG
;
Young Hui YANG
;
Jewook KANG
;
Eun Jin PARK
;
Kyooseob HA
;
Mira PARK
;
Hee Jeong YOO
Author Information
1. Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
- Publication Type:Original Article
- Keywords:
Mood disorder;
Attention deficit hyperactivity disorder;
Neuropsychology;
Endophenotype;
High-risk;
Offspring
- MeSH:
Attention Deficit Disorder with Hyperactivity;
Checklist;
Child Behavior;
Child*;
Endophenotypes;
Humans;
Intelligence;
Mood Disorders*;
Neuropsychological Tests;
Neuropsychology;
Parents*;
Pilot Projects*;
Wisconsin
- From:Psychiatry Investigation
2014;11(1):65-75
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: We aimed to investigate the neurocognitive and behavioral endophenotypes of premorbid mood disorder. We compared intelligence, neuropsychological functioning, and behavioral problems among three groups: 1) a high-risk group [attention-deficit hyperactivity disorder (ADHD) children of parents with a history of a mood disorder], 2) a low-risk group (ADHD children of parents without a history of a mood disorder), and 3) normal comparison subjects. METHODS: We used the Korean Educational Development Institute Wechsler Intelligence Scale for Children-Revised (KEDI-WISC-R), the Stroop Color Word Interference Test (Stroop), the Wisconsin Card Sorting Test (WCST), and the Rey-Osterrieth Complex Figure Test (RCFT) as neurocognitive measures, and we used the Child Behavior Checklist (CBCL) as a behavioral measure. Performance on these neuropsychological tests and score on the CBCL of 18 high-risk children were compared to those of 20 low-risk children and 24 healthy children. We also assessed the children's current mood state and familial functioning to control for the confounding effects of these variables. RESULTS: Compared to low-risk and healthy children, high-risk children were impaired on the Picture Completion and Stroop Word subtest and showed higher scores on the CBCL subscales representing internalizing symptoms. These significant group differences persisted even after adjustment for the children's current mood state and familial functioning. CONCLUSION: Neuropsychological deficits in the offspring of parents with a mood disorder may be associated with the current mood state rather than with innate characteristics, while their internalizing symptoms may partially stem from innate characteristics that are endophenotypes of a premorbid mood disorder.
