Serum Levels of Brain-Derived Neurotrophic Factor at 4 Weeks and Response to Treatment with SSRIs.
- Author:
Reiji YOSHIMURA
1
;
Taro KISHI
;
Hikaru HORI
;
Asuka KATSUKI
;
Atsuko SUGITA-IKENOUCHI
;
Wakako UMENE-NAKANO
;
Kiyokazu ATAKE
;
Nakao IWATA
;
Jun NAKAMURA
Author Information
1. Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan. yoshi621@med.uoeh-u.ac.jp
- Publication Type:Original Article
- Keywords:
Brain-derived neurotrophic factor;
Serum;
Depression;
Response;
Selective serotonin reuptake inhibitor
- MeSH:
Antidepressive Agents;
Brain-Derived Neurotrophic Factor*;
Depression;
Depressive Disorder, Major;
Humans;
Serotonin Uptake Inhibitors;
Sertraline
- From:Psychiatry Investigation
2014;11(1):84-88
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: It is important to predict a response to an antidepressant in early time after starting the antidepressant. We previously reported that serum brain-derived neurotrophic factor (BDNF) levels in responders to treatment with antidepressants were increased, whereas, those in nonresponders were not. Therefore, we hypothesized that the changes in serum levels of BDNF from baseline (T0) to 4 weeks (T4) after treatment with selective serotonin reuptake inhibitors (SSRIs) predict the response to the treatment at 8 weeks (T8) in depressed patients. To confirm the hypothesis, we measured serum BDNF at T0, T4, and T8 during the treatment with SSRIs (paroxetine, sertraline, and fluvoxamine). METHODS: One hundred fifty patients (M/F; 51/99, age; 50.4+/-15.1 years) met major depressive disorder (MDD) using by DSM-IV-TR enrolled in the present study. We measured serum BDNF concentrations at T0, T4, and T8 in patients with MDD treated with SSRIs. RESULTS: The changes in serum BDNF, age, sex, dose of SSRIs, and HAMD-17 score did not predict the response to SSRIs at T8. CONCLUSION: These results suggest that the changes in serum BDNF levels from T0 to T4 could not predict the subsequent responses to SSRIs at T8.
