Effects of 5-Fluorouracil on Delayed Adjustment in Experimental Strabismus Surgery.
- Author:
Woong Chan JEON
1
;
Se Oh OH
Author Information
1. Department of Ophthalmology, Collage of Medicine, Chungbuk National University, Chunju, Korea.
- Publication Type:Original Article
- Keywords:
Adjustable strabismus surgery;
Delayed adjustment;
Postoperative adhesion;
5-fluorouracil
- MeSH:
Conjunctiva;
Fluorouracil*;
Porifera;
Rabbits;
Sclera;
Strabismus*;
Sutures
- From:Journal of the Korean Ophthalmological Society
1996;37(11):1925-1930
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Adjustable sutures increased the rate of success with a single procedure, but sometimes fails because of changes in the angle of deviation which develops a few days after surgery. Therefore, the delayed adjustment was attempted;however, the postoperative adhesion following strabismus surgery make delayed adjustment impossible. We studied 45 eyes of 25 rabbits; adjustable strabismus surgery underwent a hang-back technique in the superior rectus muscle. In experimental group, a sponge was soaked in 5-Fluorouracil, and the sponge was placed between the conjunctiva and the sclera for 5 minutes during the operation. We studied the possible time of delayed adjustment and estimated the minimal forces required for the adjustment. The experimental group A (5-Fluorouracil, 50mg/ml) allowed for a 6 day delayed adjustment after surgery, control group allowed for a 2 day delayed adjustment after surgery. These results suggest that 5-Fluorouracil may valuable resource to delayed adjustment strabismus surgery by reduce postoperative adhesion.
