A Case of Pulmonary Thromboembolism due to Congenital Antithrombin III Deficiency.
10.4046/trd.1999.47.3.394
- Author:
Hyeong Kwan PARK
1
;
Chang Min PARK
;
Kyoung Haeng KO
;
Myung Soo RIM
;
Yu Il KIM
;
Jun Hwa HWANG
;
Sung Chul LIM
;
Young Chul KIM
;
Kyung Ok PARK
Author Information
1. Pulmonary Department of Internal Medicine, Chonnam University Medical school, Kwangju, Korea. phkhs@unitel.co.kr
- Publication Type:Case Report
- Keywords:
Antithrombin III;
Pulmonary thromboembolism;
Congenital
- MeSH:
Adult;
Antithrombin III;
Antithrombin III Deficiency*;
Chest Pain;
Dyspnea;
Heparin;
Humans;
Korea;
Lung;
Mesenteric Veins;
Nuclear Family;
Perfusion;
Plasma;
Pulmonary Embolism*;
Thrombosis;
Tissue Plasminogen Activator;
Venous Thrombosis;
Warfarin
- From:Tuberculosis and Respiratory Diseases
1999;47(3):394-399
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a case of congenital and familial antithrombin III deficiency developing massive pulmonary thromboembolism. A 44-year-old man was admitted to our hospital because of sudden chest pain and severe dyspnea. Five years ago, he was operated due to a mesenteric vein thrombosis of unknown cause. On admission, radioisotopic venogram showed deep vein thrombosis and lung scintigram showed multiple segmental perfusion defects. His plasma antithrombin III level was 10.5 mg/dL which was less than 50% of normal and those of a son and two daughters were also decreased. After treatment with tissue plasminogen activator, heparin and coumadin, his symptom and lung scintigram were significantly improved. As far as we reviewed, there were very rare reports with congenital antithrombin III deficiency presenting as pulmonary thromboembolism in Korea.
